rs2227564
|
PLAU;C10orf55
|
Inflammatory Bowel Diseases
|
C |
0.800 |
GeneticVariation |
GWASDB |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
rs2227564
|
PLAU;C10orf55
|
Inflammatory Bowel Diseases
|
C |
0.800 |
GeneticVariation |
GWASCAT |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
rs2227564
|
PLAU;C10orf55
|
Blood Protein Measurement
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
rs2227564
|
PLAU;C10orf55
|
Crohn Disease
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
rs55744193
|
PLAU;C10orf55
|
Blood Protein Measurement
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
rs2227564
|
PLAU;C10orf55
|
Alzheimer's Disease
|
|
0.020 |
GeneticVariation |
BEFREE |
We identified that one functional exonic SNP (rs2227564) is associated with development of AD using the four independent case-control samples (Munich, P=0.02; Bonn, P=0.005; Brescia (Italy), P=0.001; Perth (Australia), P=0.03) and the discordant sib-pair sample (P=0.001).
|
16825285 |
2006 |
rs2227564
|
PLAU;C10orf55
|
Alzheimer's Disease
|
|
0.020 |
GeneticVariation |
BEFREE |
This meta-analysis showed that T allele of rs2227564 polymorphism in PLAU gene could increase the effects on risk of AD, and this result needs to be confirmed by further studies.
|
23813610 |
2013 |
rs1338100379
|
PLAU;C10orf55
|
Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
This translated to a 10-fold increase in tumor retention after 24 h compared to PAI-2(C161S), an effect not seen in non-target organs.
|
25231010 |
2015 |
rs145070893
|
PLAU;C10orf55
|
Meleda Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with MDM with the homozygous SLURP-1 G86R mutation may have an impaired T-cell activation.
|
20854438 |
2011 |
rs2227564
|
PLAU;C10orf55
|
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation |
BEFREE |
The PLAU P141L single nucleotide polymorphism is associated with collateral circulation in patients with coronary artery disease.
|
24952395 |
2014 |
rs2227564
|
PLAU;C10orf55
|
Myocardial Infarction
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped rs4065 [3'-UTR (untranslated region) *141C>T) and rs2227564 (Pro141Leu) in the PLAU gene as well as rs344781 (-516T>C) in the PLAUR gene in 633 MI patients and 1237 gender- and age-matched control subjects.
|
20518747 |
2010 |
rs2227564
|
PLAU;C10orf55
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
The PLAU P141L single nucleotide polymorphism is associated with collateral circulation in patients with coronary artery disease.
|
24952395 |
2014 |
rs2227564
|
PLAU;C10orf55
|
Malignant neoplasm of ovary
|
|
0.010 |
GeneticVariation |
BEFREE |
In order to elucidate the possible role of the Pro121Leu exchange in uPA and the Ala/Thr variants in the signal sequence of PAI-1 in the development and/or progression of human ovarian cancer, we studied the presence of these mutants or variants in a series of 22 ovarian cancer tissues.
|
9194591 |
1997 |
rs2227564
|
PLAU;C10orf55
|
ovarian neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
In order to elucidate the possible role of the Pro121Leu exchange in uPA and the Ala/Thr variants in the signal sequence of PAI-1 in the development and/or progression of human ovarian cancer, we studied the presence of these mutants or variants in a series of 22 ovarian cancer tissues.
|
9194591 |
1997 |
rs2227564
|
PLAU;C10orf55
|
Carcinoma, Ovarian Epithelial
|
|
0.010 |
GeneticVariation |
BEFREE |
In order to elucidate the possible role of the Pro121Leu exchange in uPA and the Ala/Thr variants in the signal sequence of PAI-1 in the development and/or progression of human ovarian cancer, we studied the presence of these mutants or variants in a series of 22 ovarian cancer tissues.
|
9194591 |
1997 |
rs2227564
|
PLAU;C10orf55
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
This study investigated associations of a C-to-T polymorphism of uPA (P141L, rs2227564) in exon 6 in 454 Japanese health checkup examinees (126 males and 328 females) aged 35 to 85 without a history of cancer.
|
21627387 |
2011 |
rs2227564
|
PLAU;C10orf55
|
Coronary heart disease
|
|
0.010 |
GeneticVariation |
BEFREE |
The PLAU P141L single nucleotide polymorphism is associated with collateral circulation in patients with coronary artery disease.
|
24952395 |
2014 |
rs2227564
|
PLAU;C10orf55
|
Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition to the wild-type sequence, the Pro121Leu exchange in the uPA sequence was detected in 10 out of 22 tumor tissues; 11 tumors carried exclusively the Pro121 allele; in one case exclusively the Leu121 allele was detected.
|
9194591 |
1997 |
rs2227564
|
PLAU;C10orf55
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
This study investigated associations of a C-to-T polymorphism of uPA (P141L, rs2227564) in exon 6 in 454 Japanese health checkup examinees (126 males and 328 females) aged 35 to 85 without a history of cancer.
|
21627387 |
2011 |
rs2227564
|
PLAU;C10orf55
|
Blood Coagulation Disorders
|
|
0.010 |
GeneticVariation |
BEFREE |
For instance, in a number of variants related to clotting disorders, the phenotype-associated allele is a human genome reference allele (rs6025, rs6003, rs1799983, and rs2227564 using the assembly hg19).
|
29334895 |
2018 |
rs4065
|
PLAU;C10orf55
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic regression analysis revealed that individuals with uPA rs4065 TT genotype have higher odds ratios (ORs) for lung cancer.
|
20937265 |
2011 |
rs4065
|
PLAU;C10orf55
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic regression analysis revealed that individuals with uPA rs4065 TT genotype have higher odds ratios (ORs) for lung cancer.
|
20937265 |
2011 |
rs4065
|
PLAU;C10orf55
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic regression analysis revealed that individuals with uPA rs4065 TT genotype have higher odds ratios (ORs) for lung cancer.
|
20937265 |
2011 |
rs4065
|
PLAU;C10orf55
|
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results revealed that genetic polymorphisms of the uPA rs4065 C/T and uPAR rs344781 (-516 T/C) were associated with the susceptibility and severity of NSCLC.
|
20937265 |
2011 |
rs756402191
|
PLAU;C10orf55
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
The lung-enriched p53 mutants V157F and R158L/P regulate a gain of function transcriptome in lung cancer.
|
31067569 |
2020 |